Mendelian Inheritance and Classical Genetics


Let us review on the basics of breeding….

Mendel’s Laws of Inheritance

  1. Law of Dominance 
    • Some alleles are dominant while others are recessive; an organism with at least one dominant allele will display the effect of the dominant allele.
  2. Law of Segregation 
    • During gamete formation, the alleles for each gene segregate from each other so that each gamete carries only one allele for each gene.
  3. Law of Independent Assortment 
    • Genes for different traits can segregate independently during the formation of gametes.

Classical Genetics Terminologies

  1. Gene is the molecular unit of heredity of a living organism.
  2. Allele is one of a number of alternative forms of the same gene or same genetic locus.
  3. Diploid cells have two homologous copies of each chromosome, usually one from the mother and one from the father.
  4. Chromosone is a structure of DNAprotein, and RNA found in cells. It is a single piece of coiled DNA containing many genesregulatory elements and other nucleotide sequences.
  5. Phenotype is the composite of an organism‘s observable characteristics or traits, such as its morphologydevelopment, biochemical or physiological properties, phenologybehavior, and products of behavior (such as a bird’s nest). 
  6. Genotype is the genetic makeup of a cell, an organism, or an individual usually with reference to a specific characteristic under consideration.
  7. Homozygous; A cell is said to be homozygous for a particular gene when identical alleles of the gene are present on both homologous chromosomes. The cell or organism in question is called a homozygote.
  8. Heterozygous; diploid organism is heterozygous at a gene locus when its cells contain two different alleles of a gene.

– Gameness til the End

Classical genetics

From Wikipedia, the free encyclopedia

Classical genetics is the branch of genetics based solely on visible results of reproductive acts. It is the oldest discipline in the field of genetics, going back to the experiments of Gregor Mendel who made it possible to identify the basic mechanisms of heredity. Subsequently, these mechanisms have been studied and explained at the molecular level.

It consists of the technique and methodologies of genetics that predate the advent of molecular biology. A key discovery of classical genetics in eukaryotes was genetic linkage. The observation that some genes do not segregate independently at meiosis broke the laws of Mendelian inheritance, and provided science with a way to map characteristics to a location on the chromosomes. Linkage maps are still used today, especially in breeding for plant improvement.

After the discovery of the genetic code and such tools of cloning as restriction enzymes, the avenues of investigation open to geneticists were greatly broadened. Some classical genetic ideas have been supplanted with the mechanistic understanding brought by molecular discoveries, but many remain intact and in use. Classical genetics is often contrasted with reverse genetics, and aspects of molecular biology are sometimes referred to as molecular genetics.

Basic definitions

At the base of classical genetics is the concept of a gene, the hereditary factor tied to a particular simple feature (or character). One can study using the methods of classical genetics a character which contribute differently to multiple genes; such genes are said to be alleles and in most cases there are two: these correspond at the molecular level to the two copies of the gene present in diploid organisms in the two chromosomes. The different ways in which it manifests itself in nature are called phenotypes. The set of genes for one or more characters possessed by an individual is the genotype. An individual whose two alleles for the determination of a character are equal is called homozygous (AA-aa), if different from each other it is called heterozygous (Aa).

Mendelian inheritance

From Wikipedia, the free encyclopedia

Gregor Mendel, the German-speaking Augustinian monk who founded the modern science of genetics.

Mendelian inheritance was initially derived from the work of Gregor Johann Mendel published in 1865 and 1866 which was re-discovered in 1900. It was initially very controversial. When Mendel’s theories were integrated with the chromosome theory of inheritance by Thomas Hunt Morgan in 1915, they became the core of classical genetics.


  • 1 History
  • 2 Mendel’s laws
    • 2.1 Law of Segregation (the “First Law”)
    • 2.2 Law of Independent Assortment (the “Second Law”)
    • 2.3 Law of Dominance (the “Third Law”)
  • 3 Mendelian trait
  • 4 Non-Mendelian inheritance
  • 5 See also
  • 6 References
  • 7 Notes
  • 8 External links


The laws of inheritance were derived by Gregor Mendel, a nineteenth-century Austrian monk conducting hybridization experiments in garden peas (Pisum sativum). Between 1856 and 1863, he cultivated and tested some 5,000 pea plants. From these experiments, he induced two generalizations which later became known as Mendel’s Principles of Heredity or Mendelian inheritance. He described these principles in a two-part paper, Experiments on Plant Hybridization, that he read to the Natural History Society of Brno on February 8 and March 8, 1865, and which was published in 1866.

Mendel’s conclusions were largely ignored. Although they were not completely unknown to biologists of the time, they were not seen as generally applicable, even by Mendel himself, who thought they only applied to certain categories of species or traits. A major block to understanding their significance was the importance attached by 19th-century biologists to the apparent blending of inherited traits in the overall appearance of the progeny, now known to be due to multigene interactions, in contrast to the organ-specific binary characters studied by Mendel. In 1900, however, his work was “re-discovered” by three European scientists, Hugo de Vries, Carl Correns, and Erich von Tschermak. The exact nature of the “re-discovery” has been somewhat debated: De Vries published first on the subject, mentioning Mendel in a footnote, while Correns pointed out Mendel’s priority after having read De Vries’s paper and realizing that he himself did not have priority. De Vries may not have acknowledged truthfully how much of his knowledge of the laws came from his own work, or came only after reading Mendel’s paper. Later scholars have accused Von Tschermak of not truly understanding the results at all.

Regardless, the “re-discovery” made Mendelism an important but controversial theory. Its most vigorous promoter in Europe was William Bateson, who coined the terms “genetics” and “allele” to describe many of its tenets. The model of heredity was highly contested by other biologists because it implied that heredity was discontinuous, in opposition to the apparently continuous variation observable for many traits. Many biologists also dismissed the theory because they were not sure it would apply to all species. However, later work by biologists and statisticians such as R. A. Fisher showed that if multiple Mendelian factors were involved in the expression of an individual trait, they could produce the diverse results observed. Thomas Hunt Morgan and his assistants later integrated the theoretical model of Mendel with the chromosome theory of inheritance, in which the chromosomes of cells were thought to hold the actual hereditary material, and created what is now known as classical genetics, which was extremely successful and cemented Mendel’s place in history.

Mendel’s findings allowed other scientists to predict the expression of traits on the basis of mathematical probabilities. A large contribution to Mendel’s success can be traced to his decision to start his crosses only with plants he demonstrated were true-breeding. He also only measured absolute (binary) characteristics, such as color, shape, and position of the offspring, rather than quantitative characteristics. He expressed his results numerically and subjected them to statistical analysis. His method of data analysis and his large sample size gave credibility to his data. He also had the foresight to follow several successive generations (f2, f3) of pea plants and record their variations. Finally, he performed “test crosses” (back-crossing descendants of the initial hybridization to the initial true-breeding lines) to reveal the presence and proportion of recessive characters.

Mendel’s laws

A Punnett square for one of Mendel’s pea plant experiments.

Mendel discovered that, when he crossed purebred white flower and purple flower pea plants (the parental or P generation), the result was not a blend. Rather than being a mix of the two, the offspring (known as the F1 generation) was purple-flowered. When Mendel self-fertilized the F1 generation pea plants, he obtained a purple flower to white flower ratio in the F2 generation of 3 to 1. The results of this cross are tabulated in the Punnett square to the right.

He then conceived the idea of heredity units, which he called “factors”. Mendel found that there are alternative forms of factors—now called genes—that account for variations in inherited characteristics. For example, the gene for flower color in pea plants exists in two forms, one for purple and the other for white. The alternative versions of a gene are now called alleles. For each biological trait, an organism inherits two alleles, one from each parent. These alleles may be the same or different. An organism that has two identical alleles for a gene is said to be homozygous for that gene (and is called a homozygote). An organism that has two different alleles for a gene is said be heterozygous for that gene (and is called a heterozygote).

Mendel also hypothesized that allele pairs separate randomly, or segregate, from each other during the production of gametes: egg and sperm. Because allele pairs separate during gamete production, a sperm or egg carries only one allele for each inherited trait. When sperm and egg unite at fertilization, each contributes its allele, restoring the paired condition in the offspring. This is called the Law of Segregation. Mendel also found that each pair of alleles segregates independently of the other pairs of alleles during gamete formation. This is known as the Law of Independent Assortment.

The genotype of an individual is made up of the many alleles it possesses. An individual’s physical appearance, or phenotype, is determined by its alleles as well as by its environment. The presence of an allele does not mean that the trait will be expressed in the individual that possesses it. If the two alleles of an inherited pair differ (the heterozygous condition), then one determines the organism’s appearance and is called the dominant allele; the other has no noticeable effect on the organism’s appearance and is called the recessive allele. Thus, in the example above dominant purple flower allele will hide the phenotypic effects of the recessive white flower allele. This is known as the Law of Dominance. We use upper case letters to represent dominant alleles and lowercase letters to represent recessive alleles.

Mendel’s Laws of Inheritance
Law Definition
Law of Dominance Some alleles are dominant while others are recessive; an organism with at least one dominant allele will display the effect of the dominant allele.
Law of Segregation During gamete formation, the alleles for each gene segregate from each other so that each gamete carries only one allele for each gene.
Law of Independent Assortment Genes for different traits can segregate independently during the formation of gametes.

In the pea plant example above, the capital “P” represents the dominant allele for purple flowers and lowercase “p” represents the recessive allele for white flowers. Both parental plants were true-breeding, and one parental variety had two alleles for purple flowers (PP) while the other had two alleles for white flowers (pp). As a result of fertilization, the F1 hybrids each inherited one allele for purple flowers and one for white. All the F1 hybrids (Pp) had purple flowers, because the dominant P allele has its full effect in the heterozygote, while the recessive p allele has no effect on flower color. For the F2 plants, the ratio of plants with purple flowers to those with white flowers (3:1) is called the phenotypic ratio. The genotypic ratio, as seen in the Punnnett square, is 1 PP : 2 Pp : 1 pp.

Law of Segregation (the “First Law”)

Figure 1 Dominant and recessive phenotypes.
(1) Parental generation.
(2) F1 generation.
(3) F2 generation. Dominant (red) and recessive (white) phenotype look alike in the F1 (first) generation and show a 3:1 ratio in the F2 (second) generation.

The Law of Segregation states that every individual contains a pair of alleles for each particular trait which segregate or separate during cell division(assuming diploidy) for any particular trait and that each parent passes a randomly selected copy (allele) to its offspring. The offspring then receives its own pair of alleles of the gene for that trait by inheriting sets of homologous chromosomes from the parent organisms. Interactions between alleles at a single locus are termed dominance and these influence how the offspring expresses that trait (e.g. the color and height of a plant, or the color of an animal’s fur). Book definition: The law of segregation states that the two alleles for a heritable character segregate (separate from each other) during gamete formation and end up in different gametes.*

More precisely, the law states that when any individual produces gametes, the copies of a gene separate so that each gamete receives only one copy (allele). A gamete will receive one allele or the other. The direct proof of this was later found following the observation of meiosis by two independent scientists, the German botanist Oscar Hertwig in 1876, and the Belgian zoologist Edouard Van Beneden in 1883. Paternal and maternal chromosomes get separated in meiosis and the alleles with the traits of a character are segregated into two different gametes. Each parent contributes a single gamete, and thus a single, randomly successful allele copy to their offspring and fertilization.

Law of Independent Assortment (the “Second Law”)

Figure 2 Dihybrid cross. The phenotypes of two independent traits show a 9:3:3:1 ratio in the F2generation. In this example, coat color is indicated by B (brown, dominant) or b (white), while tail length is indicated by S (short, dominant) or s(long). When parents are homozygous for each trait (SSbb and ssBB), their children in the F1generation are heterozygous at both loci and only show the dominant phenotypes (SsbB). If the children mate with each other, in the F2 generation all combinations of coat color and tail length occur: 9 are brown/short (purple boxes), 3 are white/short (pink boxes), 3 are brown/long (blue boxes) and 1 is white/long (green box).

The Law of Independent Assortment, also known as “Inheritance Law”, states that separate genes for separate traits are passed independently of one another from parents to offspring. That is, the biological selection of a particular gene in the gene pair for one trait to be passed to the offspring has nothing to do with the selection of the gene for any other trait. More precisely, the law states that alleles of different genes assort independently of one another during gamete formation. While Mendel’s experiments with mixing one trait always resulted in a 3:1 ratio (Fig. 1) between dominant and recessive phenotypes, his experiments with mixing two traits (dihybrid cross) showed 9:3:3:1 ratios (Fig. 2). But the 9:3:3:1 table shows that each of the two genes is independently inherited with a 3:1 phenotypic ratio. Mendel concluded that different traits are inherited independently of each other, so that there is no relation, for example, between a cat’s color and tail length. This is actually only true for genes that are not linked to each other.

Independent assortment occurs in eukaryotic organisms during meiotic metaphase I, and produces a gamete with a mixture of the organism’s chromosomes. The physical basis of the independent assortment of chromosomes is the random orientation of each bivalent chromosome along the metaphase plate with respect to the other bivalent chromosomes. Along with crossing over, independent assortment increases genetic diversity by producing novel genetic combinations.

Of the 46 chromosomes in a normal diploid human cell, half are maternally derived (from the mother’s egg) and half are paternally derived (from the father’s sperm). This occurs as sexual reproduction involves the fusion of two haploid gametes (the egg and sperm) to produce a new organism having the full complement of chromosomes. During gametogenesis—the production of new gametes by an adult—the normal complement of 46 chromosomes needs to be halved to 23 to ensure that the resulting haploid gamete can join with another gamete to produce a diploid organism. An error in the number of chromosomes, such as those caused by a diploid gamete joining with a haploid gamete, is termed aneuploidy.

In independent assortment, the chromosomes that result are randomly sorted from all possible combinations of maternal and paternal chromosomes. Because gametes end up with a random mix instead of a pre-defined “set” from either parent, gametes are therefore considered assorted independently. As such, the gamete can end up with any combination of paternal or maternal chromosomes. Any of the possible combinations of gametes formed from maternal and paternal chromosomes will occur with equal frequency. For human gametes, with 23 pairs of chromosomes, the number of possibilities is 223 or 8,388,608 possible combinations. The gametes will normally end up with 23 chromosomes, but the origin of any particular one will be randomly selected from paternal or maternal chromosomes. This contributes to the genetic variability of progeny.

Law of Dominance (the “Third Law”)

Mendel’s Law of Dominance states that recessive alleles will always be masked by dominant alleles. Therefore, a cross between a homozygous dominant and a homozygous recessive will always express the dominant phenotype, while still having a heterozygous genotype. Law of Dominance can be explained easily with the help of a mono hybrid cross experiment:- In a cross between two organisms pure for any pair (or pairs) of contrasting traits (characters), the character that appears in the F1 generation is called “dominant” and the one which is suppressed (not expressed) is called “recessive.” Each character is controlled by a pair of dissimilar factors. Only one of the characters expresses. The one which expresses in the F1 generation is called Dominant. It is important to note however, that the law of dominance is significant and true but is not universally applicable.

Mendelian trait

A Mendelian trait is one that is controlled by a single locus in an inheritance pattern. In such cases, a mutation in a single gene can cause a disease that is inherited according to Mendel’s laws. Examples include sickle-cell anemia, Tay-Sachs disease, cystic fibrosis and xeroderma pigmentosa. A disease controlled by a single gene contrasts with a multi-factorial disease, like arthritis, which is affected by several loci (and the environment) as well as those diseases inherited in a non-Mendelian fashion.

Non-Mendelian inheritance

Main article: Non-Mendelian inheritance

The color alleles of Mirabilis jalapa show incomplete dominance.
(1) Parental generation. (2) F1 generation. (3) F2 generation. The “red” and “white” allele together make a “pink” phenotype, resulting in a 1:2:1 ratio of red:pink:whitein the F2 generation.

Mendel explained inheritance in terms of discrete factors—genes—that are passed along from generation to generation according to the rules of probability. Mendel’s laws are valid for all sexually reproducing organisms, including garden peas and human beings. However, Mendel’s laws stop short of explaining some patterns of genetic inheritance. For most sexually reproducing organisms, cases where Mendel’s laws can strictly account for the patterns of inheritance are relatively rare. Often, the inheritance patterns are more complex.

The F1 offspring of Mendel’s pea crosses always looked like one of the two parental varieties. In this situation of “complete dominance,” the dominant allele had the same phenotypic effect whether present in one or two copies. But for some characteristics, the F1 hybrids have an appearance in between the phenotypes of the two parental varities, an effect called incomplete dominance. When red Mirabilis jalapa or four o’clock flowers are crossed with white four o’clock flowers, all the F1 hybrids have pink flowers. This third phenotype results from flowers of the heterzygote having less red pigment than the red homozygotes. Incomplete dominance does not support the blending hypothesis, which would predict that the red and white traits could never be retrieved from the pink hybrids. The F2 offspring appear in a phenotypic ratio of 1 red to 2 pink to 1 white, because the red and white alleles segregate during gamete formation in the pink F1 hybrids. In incomplete dominance, the phenotypes of heterozygotes differ from the two homozygous varieties, and the genotypic ratio and the phenotypic ratio are both 1:2:1 in the F2 generation.

See also


  1. ^:a b c Henig, Robin Marantz (2009). The Monk in the Garden : The Lost and Found Genius of Gregor Mendel, the Father of Modern Genetics. Houghton Mifflin. ISBN 0-395-97765-7. “The article, written by an Austrian monk named Gregor Johann Mendel…”
  2. Jump up^ See Mendel’s paper in English: Gregor Mendel (1865). “Experiments in Plant Hybridization”.
  3. Jump up^ Perez, Nancy. “Meiosis”. Retrieved 2007-02-15.


  • Peter J. Bowler (1989). The Mendelian Revolution: The Emergence of Hereditarian Concepts in Modern Science and Society. Johns Hopkins University Press.
  • Atics, Jean. Genetics: The life of DNA. ANDRNA press.
  • Reece, Jane B., and Neil A. Campbell. “Mendel and the Gene Idea.” Campbell Biology. 9th ed. Boston: Benjamin Cummings / Pearson Education, 2011. 265. Print.

External links

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